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Invited Speaker: Dr. Serge Dos Santos

Invited Speaker: Dr.  Serge Dos Santos

Invited Speaker: Dr. Serge Dos Santos

High-frequency ultrasounds for multiscale hysteretic properties of biomaterials: nonlinear time reversal imaging and prescriptive data analysis within Health 4.0

Serge DOS SANTOS (M’02, SM’16), PhD. received in 1995 the Master Degree of Physics with the mention “Molecular Spectroscopy and Nonlinear Physics” from the University of Dijon, France. He worked at the FEMTO Institute (LPMO-CNRS), Besançon, France, on the study of the origin of low frequency fluctuations in ultrastable oscillators. He obtained a Ph.D. degree in Engineering Science in 1998 for its contribution for understanding the link between low frequency noise and nonlinearity in synchonized systems. Then he joined the biomedical ultrasonic group “GIP Ultrasons” created by Pr. Léandre Pourcelot at Tours, France, working for the development of new medical and Non Destructive Testing (NDT) applications of Nonlinear Acoustics for Ultrasound Imaging. He is Associate Professor, Hab. Dir. Rech. at INSA Centre Val de Loire, Blois, France since 1998, leading as Project Manager on “Industry 4.0” the Digital Transformation within the INSA Group. His research interests at Inserm U1253 are in the broad area of nonlinear acoustics for NDT and biomedical applications, with a special focus on signal processing and instrumentation, nonlinear sources localization, and multimodal imaging involving nonlinear time reversal methods and neuromorphic electronics using memristors. His bibliography contains more than 227 references (Scopus H-index 2021: 10) with 54 co-authors, including 1 book, 2 book chapters, 21 reviewed contributions, 164 international conferences (27 invited) and 41 seminars or lectures. For his outstanding contribution to the growth and dissemination of Non Destructive Testing knowledge to the worldwide community, he was awarded by Academia NDT International as a Full Member (ECNDT 2010, Moscow), responsible of the “Signal Processing Chapter”, member of the Council since 2014 and Vice-President since October 2021. He was elected in the IIAV Board of Directors during the period 2018-2022, and coopted in the Panel “IIAV Distinguished Fellowship and Fellowship Committee for IIAV non-members” in 2020. Since May 2020, he contributes to the NDE4.0 Global Ambassadors Panel. As an IEEE Senior Member, he is highly involved in the IEEE France EMBS Chapter and “Actions for Industry” under the R8 Region. He was chosen as a member of the Organization or Scientific Committee (TPC) of international conferences and workshops: NDT in Progress since 2011, ICNDT2013, ICNDT2017; ECNDT 2014; IEEE BEC2014, IEEE BEC2016, ICSV22, IEEE IUS2016, WCNDT2016, ICSV23, ICSV24, FCAC2018, IEEE BEC 2018, ICFCTA 2019; ICSV25, ICSV26, FA2020, ICSV27, NDE4.0 2021, IEEE RTSI2021, ICSV28

High-frequency ultrasounds for multiscale hysteretic properties of biomaterials: nonlinear time reversal imaging and prescriptive data analysis within Health 4.0


 Serge Dos Santos1*, Djamel Remache1, Halima Ghorbel-Feki1, Ali Masood2, Ilenia Cristofano1, and Martin Lints2

1 : INSA Centre Val de Loire, Blois Campus; U1253 Ibrain "Imaging and Brain" Inserm-Université de Tours, 3 rue de la Chocolaterie, CS23410, 41034 Blois, France,

2Institute of Cybernetics at Tallinn University of Technology, Akadeemia tee 21, 12618, Tallinn, Estonia

Keywords: Ultrasonics, Imaging, TR-NEWS, skin aging, echodentography, odontology


Since last decades, real-time high-resolution imaging of biomaterials including bone, skin and tooth has been achieved using high-frequency ultrasound scanning systems. In this keynote, feasibility for characterization of skin and tooth aging using high-frequency ultrasonic imaging is demonstrated. The aim of this paper is to present an acousto-mechanical based experiment using the Nonlinear Time Reversal signal processing tool known to extract, in a complex medium, sources of multiscale hysteretic nonlinearity responsible of degradation processes[1]. The paper presents the TR-NEWS device which is associated to the development of a phenomenological characterization of material local elastic properties working at 50 MHz allowing the measurements of degradation and aging of complex biomaterials. Tested for biomedical applications on ex vivo skin and human tooth, the well-known complexity of biomaterials constitutes a strong advantage for the TR-NEWS efficiency[2]. Linear and nonlinear behavior of elasticity are measured locally thanks to a mechanical loading conducted with an Instron loading machine specifically optimized for biomaterials[3]. Various materials have been tested for the validation of concept (such as polymers, multiscale elastic layer in contact on complex reverberant bio-materials) before applications. Signal and data analysis using digital correlation images are conducted with the objective of an open data library compatible with the concept of Industry 4.0 applied to the healthcare community, suitable within odontology or for the cosmetic industry[4].

Figure 1 : TR-NEWS experimental set-up using digital correlation images

1. Lints, M., Salupere, A., & Dos Santos, S. (2020). Numerical simulation of ultrasonic time reversal on defects in carbon fibre reinforced polymer. Wave Motion, 94, 102526.

2. Dos Santos, S. (2020). Advanced Ground Truth Multimodal Imaging Using Time Reversal (TR) Based Nonlinear Elastic Wave Spectroscopy (NEWS): Medical Imaging Trends Versus Non-destructive Testing Applications. In Recent Advances in Mathematics and Technology (pp. 55-87). Birkhäuser, Cham.

3. Remache, D., Caliez, M., Gratton, M., & Dos Santos, S. (2018). The effects of cyclic tensile and stress-relaxation tests on porcine skin. Journal of the mechanical behavior of biomedical materials, 77, 242-249.

4. S. Dos Santos et al., "Acousto-Mechanical Instrumentation of Multiscale Hysteretic Memristive Properties of the Skin with Nonlinear Time Reversal Imaging," 2017 Cosmetic Measurements And Testing (COSMETIC), 2017