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Invited Speaker: Dr. Sedat Nizamoglu

Invited Speaker: Dr. Sedat Nizamoglu

Invited Speaker: Dr. Sedat Nizamoglu

Novel Optoelectronic Biointerfaces for Photostimulation of Neurons

Sedat Nizamoglu is an associate professor in the department of Electrical and Electronics Engineering and the director of IDEALAB (Innovative Devices and Interfaces Laboratory) at Koc University, Istanbul, supported by ERC (European Research Council). Immediately after receiving his PhD degree at Bilkent University in 2011, he continued as a Bullock-Wellman Fellow with a joint affiliation with Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital in USA. His research focuses on the demonstration of innovative bioelectronic and optoelectronic devices and interfaces for the applications to energy, medicine, and environment. He has published more than 70 research papers in prestigious journals including Nature Communications, Nature Photonics, ACS Nano and Nano Letters. He received numerous awards such as IEEE Research Encouragement Award (Turkey), Encouragement Award by TUBITAK (Turkish NRF), Outstanding Young Scientist Award by Turkish Academy of Sciences and Science Academy,  Innovation Award by European Technology Platform for Photonics and SPIE Scholarship Award in Optical Science and Engineering. He was also recognized by MIT Technology Review as Innovator Under 35 Turkey.

Novel Optoelectronic Biointerfaces for Photostimulation of Neurons

Sedat Nizamoglu*

* Department of Electrical and Electronics Engineering, Koç University, Istanbul, 34450, Turkey

Optoelectronic conversion of light to ionic currents in liquid cellular environments offers a non-genetic and wireless control methodology of neural activity. In my talk I will start with the fundamentals of the operation of the optoelectronic biointerfaces. Then I will discuss nanoengineering principles of biointerfaces at device and quantum dot level that allow for the bidirectional photoelectrochemical current generation and enable light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons.1 Efficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems and inspired by the photosynthesis of the plants we adapted Förster-type non-radiative energy transfer to the biointerfaces.2 Moreover, I will discuss how plasmonics can be used for optoelectronic biointerfaces.3 In addition, we developed novel quantum dots such as InP/ZnO and AlSb that can lead to efficient and safe photostimulation of neurons.4-6 Finally, I will discuss our recent progress on tissue-like soft optoelectronic biointerfaces. These findings pave the way toward superior neural prosthesis for retina against blindness.




1.             Karatum, O.; Aria, M. M.; Eren, G. O.; Yildiz, E.; Melikov, R.; Srivastava, S. B.; Surme, S.; Dogru, I. B.; Bahmani Jalali, H.; Ulgut, B.; Sahin, A.; Kavakli, I. H.; Nizamoglu, S., Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons. Frontiers in Neuroscience 2021, 15 (724).

2.             Bahmani Jalali, H.; Karatum, O.; Melikov, R.; Dikbas, U. M.; Sadeghi, S.; Yildiz, E.; Dogru, I. B.; Ozgun Eren, G.; Ergun, C.; Sahin, A., Biocompatible Quantum Funnels for Neural Photostimulation. Nano letters 2019, 19 (9), 5975-5981.

3.             Melikov, R.; Srivastava, S. B.; Karatum, O.; Dogru-Yuksel, I. B.; Bahmani Jalali, H.; Sadeghi, S.; Dikbas, U. M.; Ulgut, B.; Kavakli, I. H.; Cetin, A. E., Plasmon-Coupled Photocapacitor Neuromodulators. ACS applied materials & interfaces 2020, 12 (32), 35940-35949.

4.             Bahmani Jalali, H.; Mohammadi Aria, M.; Dikbas, U. M.; Sadeghi, S.; Ganesh Kumar, B.; Sahin, M.; Kavakli, I. H.; Ow-Yang, C. W.; Nizamoglu, S., Effective neural photostimulation using indium-Based type-II quantum dots. ACS nano 2018, 12 (8), 8104-8114.

5.             Bahmani Jalali, H.; Sadeghi, S.; Sahin, M.; Ozturk, H.; Ow-Yang, C. W.; Nizamoğlu, S., Colloidal Aluminum Antimonide Quantum Dots. Chemistry of Materials 2019.

6.             Han, M.; Bahmani Jalali, H.; Yildiz, E.; Qureshi, M. H.; Şahin, A.; Nizamoglu, S., Photovoltaic neurointerface based on aluminum antimonide nanocrystals. Communications Materials 2021, 2 (1), 19.